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English: The chromosomal DNA within the nucleoid is segregated into independent supercoiled topological domains A. An illustration of a single topological domain of a supercoiled DNA. A single double-stranded cut anywhere would be sufficient to relax the supercoiling tension of the entire domain. B. An illustration of multiple topological domains in a supercoiled DNA molecule. A presence of supercoiling-diffusion barriers segregates a supercoiled DNA molecule into multiple topological domains. Hypothetical supercoiling diffusion barriers are represented as green spheres. As a result, a single double-stranded cut will only relax one topological domain and not the others. Plectonemic supercoils of DNA within the E. coli nucleoid are organized into several topological domains, but only four domains with a different number of supercoils are shown for simplicity.
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Uppruni
doi:10.1371/journal.pgen.1008456 Verma SC, Qian Z, Adhya SL (2019) Architecture of the Escherichia coli nucleoid. PLoS Genet 15(12): e1008456.
tilvísun höfundarréttar – Þú verður að tilgreina viðurkenningu á höfundarréttindum, gefa upp tengil á notkunarleyfið og gefa til kynna ef breytingar hafa verið gerðar. Þú getur gert þetta á einhvern ásættanlegan máta, en ekki á nokkurn þann hátt sem bendi til þess að leyfisveitandinn styðji þig eða notkun þína á verkinu.
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